Physician's Decision Process for Disease Diagnosis of Overlapping Syndrome in Liver Disease using Soft Computing Model

An understanding towards the overlapping syndromes is essential to cope up the liver disease with the paradigm shift which is underway. Autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) all belong to the family of autoimmune liver diseases. This can result in a transient phenotypic overlap or a combined syndrome with characteristics of both diseases. It demonstrates mixed clinical presentations of immune-mediated liver injury. Due to overlapping features of AIH, some patients connote such phenotype that leads to a dubious diagnosis of any disease. In some cases, this type of diagnosis system causes the patient’s death in the absence of well-validated diagnostic criteria. Some improvements in diagnosis instrumentation and automation that has become to capture experience of any veteran person, is needed. Simulation of such diagnosis experience is extremely important as it leads to knowledge discovery. In this paper, we gave a soft computing model based disease diagnosis system for overlapping syndrome of liver disease. It helped the in physician’s decision process that comes after long experience in new individual.